Wilsong Glentress Captain at OR Trail DNA Test Results

CHROMOSOME 2
Chromosome 2

THE RESULTS OF THIS TEST
Clear
TEST RESULT
Glentress Captain at OR Trail has two healthy alleles at CUBN.

Imerslund-Grasbeck Syndrome, Selective Cobalamin Malabsorption
(CUBN Exon 53)
CONDITION
CUBN (Exon 53)
GENE NAME
NN
CLEAR
ND
CARRIER
DD
AT RISK
Recessive
INHERITANCE TYPE
DESCRIPTION
This is a treatable gastrointestinal disease where dogs cannot absorb cobalamin, often causing them to be runty with poor energy levels. Cobalamin is
required for synthesis of certain amino acids and is an important factor for a number of other metabolic processes. Dogs cannot generate their own
cobalamin but must consume it in their diet. However, because dogs with IGS cannot absorb cobalamin from their meals, they usually present to the vet
as puppies for being runty and having a poor energy level. They also display a number of abnormalities on physical exams including low red blood cell
counts and abnormally slow heart rate. If left untreated, cobalamin deficiency can also cause neurologic effects, which could manifest as vomiting or
seizures. Fortunately, IGS is treatable with regular injections of cobalamin. Early treatment is associated with the best outcome. IGS has been described
in a number of dog breeds but the genetics have only been defined in the Border Collie and the Beagle; Embark tests for both of these mutations.

CHROMOSOME 31
Chromosome 31
THE RESULTS OF THIS TEST ARE PROVISIONAL
Clear
TEST RESULT
Glentress Captain at OR Trail has two healthy alleles at AP3B1.

Cyclic Neutropenia, Gray Collie Syndrome
(AP3B1 Exon 20)
CONDITION
AP3B1 Exon 20
GENE NAME
NN
CLEAR
NI
CARRIER
II
AT RISK
Recessive
INHERITANCE TYPE
DESCRIPTION
This is a disease of neutrophil, a type of white blood cell, production, where the number of circulating neutrophils drops precipitously, leaving
dogs prone to bacterial infections, and then slowly returns to normal over a 10 to 12 day course. If caught early, infections can be treated with
appropriate supportive care. Cyclic neutropenia was first identified in lineages of gray Collies and is also known as Gray Collie Syndrome.

CHROMOSOME 16
Chromosome 16
THE RESULTS OF THIS TEST ARE PROVISIONAL
Clear
TEST RESULT
Glentress Captain at OR Trail has two healthy alleles at CLCN1.

Myotonia Congenita
(CLCN1 Exon 23)
CONDITION
CLCN1 (Exon 23)
GENE NAME
NN
CLEAR
NI
CARRIER
II
AT RISK
Recessive
INHERITANCE TYPE
DESCRIPTION
This condition is characterized by prolonged muscle contraction and stiffness that usually resolves with normal exercise, though physical
therapy can be beneficial. The genetic basis has been best characterized in the Miniature Schnauzer and the Chow Chow, though it has been
reported sporadically in other dog breeds. Affected dogs present as puppies for prolonged muscle contractions, especially after resting. This
leads to visibly appreciable muscle rigidity and a stiff, hopping gait. The tongue muscle is often affected as well, causing affected dogs to have a
characteristic protruding tongue. Affected dogs may also have difficulty swallowing or may regurgitate their food after eating due to involuntary
muscle contractions.

CYCLIC NEUTROPENIA, GRAY COLLIE SYNDROME

IMERSLUND-GRASBECK SYNDROME, SELECTIVE COBALAMIN MALABSORPTION

HEALTH CONDITIONS